Page 86 - Tata-Trusts-Annual-Report-2022-23

The research projects were as follows:

1 Identification and characterization of small molecule inhibitors to treat Notch2 positive B-cell malignancies

2 To study molecular milieu at telomeres during oxidative stress

3 Investigate the novel role of mdc1 as an autophagy inducer and its implications in Tumorigenesis

4 Investigating the role of GR-mediated liposomal drug delivery system against OSCC and Tumor
Microenvironment for targeted therapeutics
5 Collagen- based composite sca old with sodium citrate functionalized for osteochondral
tissue engineering- in vitro and in vivo studies
6 Study of the e ect of Gut microbiota (Physiological & Pathological) on the progression of Alzheimer’s
disease using Drosophila melanogaster model of AD
7 Circadian control of c-c & c-x-c chemokine expression & its role in monocyte homing

8 Elucidation of the role of AR, AR Variants and associated signalling in conferring resistance to
androgen deprivation in prostate cancer

9 Investigating the impact of Hepatitis B virus on iron metabolism during chronic infection
10 Pharmacokinetic Assessment of P-glycoprotein Mediated Interactions: Cyclin Dependent Kinase
Inhibitor and Proton Pump Inhibitors in the Intervention of Metastatic Breast Cancer

11 Immunomodulation as an adjunctive therapy for the treatment in Fungal Endophthalmitis

12 Tissue Engineering Approach for Functional Recovery following Spinal Cord Injury

13 Studies on role of hsr lncRNA gene in immune response and heart development in Drosophila melanogaster

14 Ameliorating e ect of Gardenin A against Alcohol-induced liver disease in the Gut-Liver-Brain axis

15 Integrated analyses of genome-scale metabolic models and omics profiles to capture the
host-pathogen-environment interplay of Candida sp

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