Page 87 - Tata-Trusts-Annual-Report-2022-23

Institutional Research Grants

Leukaemia and the biology and treatment of cancer were the main areas of focus for the fiscal year 2022–2023. Of the
41 proposals received, 6 were selected for assistance, with a total funding commitment of `53.1 million over three years.

The research projects selected were on:

1 Deciphering the molecular heterogeneity in Acute Leukaemia of Ambiguous Lineage at a cellular level.
2 Role of immune surveillance in the persistence of minimal/measurable residual disease (MRD) and
pathogenesis of relapse in adult B-cell acute lymphoblastic leukaemia (B-ALL)
3 Gut microbiome in children with acute lymphoblastic leukaemia (ALL) – association with leukemogenesis,
serial surveillance and e ect on toxicity, disease outcome and immunological recovery.
4 To study the e cacy of stereotactic body radiation therapy in improving the overall survival and
tumor control by immunomodulating the tumor microenvironment in hepatocellular carcinoma patients.

5 Microbiome-metabolome axis in non-small cell lung cancer

6 A study of familial aggregation in non-small cell lung cancer in India – Role of genetic susceptibility

International Awards (research in leukaemia and diseases of the blood)
Scholarships aggregating GBP 243,000 were sanctioned during 2022-23, for 7 research projects undertaken by scholars in
UK, Spain, Croatia and Lebanon, which were as under:

1 Identification of functionally active and essential enhancers in acute myeloid leukaemia

2 Contribution of Lipid Droplets to the pathogenesis and chemoresistance of Acute Myeloid Leukaemia (ALERT)

3 Mechanisms of anti-leukemic e ects of stearoyl-coA desaturase (SCD) inhibition

4 Dissection of clonal evolution and diversification in secondary and therapy-related acute myeloid leukaemia

5 Uncovering novel therapeutic targets in leukaemia with low input proteomics

6 Molecular, Cellular, and functional Analysis of Human Clonal Haematopoiesis of Indeterminant Potential (CHIP)

7 Modelling infant AML using an organoid model of embryonic haematopoiesis

Teachers’ Training Programme
With a budget of `300,000, six online teacher training programmes covering fundamental science topics like pharmacology,
artificial intelligence, bioinformatics, biotechnology, and genome editing were also held throughout the year.

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