Page 81 - Tata-Trusts-Annual-Report-2022-23

Key findings of the study Phase 2 of the CBR-TLSA was initiated from January 2022,
and includes continued recruitment for Phase I and
• The prevalence of depression was significantly higher in development of a multimodal intervention trial for Phase II.
rural than urban subjects, with female preponderance in The baseline recruitments have crossed 1,250 individuals
both groups. Early life stressors (parental death) and with over 700 individuals under follow-up. More than 1,100
head injury were significantly more common in rural MRI assessments and over 2,300 OCT (Optical Coherence
than in urban India, whereas stroke was more Tomography) assessments have been completed. A
pronounced in urban India . 1
rodent model for vascular cognitive impairment

• The proportion of participants with hypertension, was developed in Phase I; further studies are ongoing
diabetes, and obesity was higher in the TLSA (urban) regarding behavioural analysis of the same in Phase II.
cohort than in the SANSCOG (rural) cohort. However,
the proportion of high-risk CAIDE (Cardiovascular Risk The multimodal intervention study received approval from
Factors, Aging, and Incidence of Dementia) scores was the Institutional Ethics Committee in May 2022, and
higher in the rural cohort, since lower levels of education
2
in the rural cohort were a significant contributor . recruitment for the same has been initiated. This
multimodal intervention study is the first-of-its-kind in
• Urban (CBR-TLSA) participants had a significantly India and part of the Worldwide FINGERS initiative, which
higher prevalence of metabolic syndrome than their is ongoing in China and Latin American countries.
rural counterparts, reaching an alarming 63.1% among This study is a unique, lifestyle-based, non-invasive
3
urban participants aged 65−74 years . intervention, focusing on dietary modifications, cognitive
remediation, physical exercises and yoga practices, along
• E ect of the Covid-19 pandemic on the CBR-TLSA
cohort: During the first wave, 28.8% and 5.5% had with strict control of vascular co-morbidities. This study is
depression and anxiety respectively in the rural cohort. undertaken by an expert committee comprising national
Corresponding figures in the urban cohort were 6.5% and international members supervising the interventions
and 1.7%. During the second wave, 28.8% of rural from conception to delivery with regular audits of the
subjects su ered from depression and 3.9% had anxiety, e cacy and adherence. CBR has also become a signatory
whereas corresponding figures in urban subjects were to the prestigious “Nairobi Declaration 2023,” which aims
4
13.1% and 0.66% .
to reduce the burden of dementia in developing countries
• Perceptual priming can increase or decrease with age or through scientific research.
cognitive impairment, but these changes do not covary
5
with explicit memory .
• Gamma oscillations weaken with age in healthy elderly
6
in human EEG .

• Stimulus-induced gamma rhythms are weaker in
human elderly with mild cognitive impairment and
Alzheimer’s disease .
7

1 Sundarakumar JS et al Alzheimer's & Dementia 2022, PMID: 36573020
2 Menesgere A et al.2022, Alzheimer's & Dementia 2022 PMID: 36548115
3 Sundarakumar JS* et al , EClinicalMedicine,2022. PMID: 35497067
4 Sundarakumar JS et al, Health Science Reports. 2022 Nov. PMID: 36381404
5 Zhivago, K. A. et al 2020, Frontiers in aging neuroscience, 12, 425
6 Murty, D. V et al. 2020 Neuroimage, 215, 116826
7 Murty, D. V. et al 2021.eLife.61666

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